Rosie O’Donnell reveals precise Mounjaro dosage while claiming she’s ‘never experienced’ any side effects

| July 29, 2026 | Celebrity | No Comments

Rosie O’Donnell is gradually increasing her dosage of Mounjaro.

The former talk show host discussed her experience with the weight loss medication during a recent episode of the podcast “Bleep! With Ana Navarro”.

The 64-year-old revealed to listeners, “I started with the lowest dose of 2.5 milligrams for a year… Then I moved to 5 for a year, and now I’m wrapping up my year at 7.5.” She has lost around 60 pounds over three years.

Rosie O'Donnell is seen leaving.
Rosie O’Donnell (pictured above on June 15) shared her exact Mounjaro dosage on Monday. GC Images
Rosie O'Donnell in a black patterned suit with yellow and grey accents at the Tony Awards.
The actress (pictured above on June 7) “did the lowest dose for a year.” Getty Images

The ex-host of “The View” mentioned that she plans to increase the dosage only one more time before maintaining it.

She shared, “I chose to take it slow because I’ve noticed how quick weight loss can overwhelm me due to everyone’s reactions.”

O’Donnell added, “I prefer this gradual approach. It feels good not to be sick, and I’ve never experienced any side effects at all.”

Rosie O'Donnell in a blue tracksuit and glasses, greeting fans in New York City.
After taking 2.5 milligrams, the Daytime Emmy winner (pictured above on July 24) doubled the amount for another year. BACKGRID
Rosie O'Donnell backstage after her one-woman show.
O’Donnell (pictured above in July 21) is now nearly one year into taking 7.5 milligrams. Bruce Glikas/Getty Images

When Navarro inquired if she had ever needed to rush to the restroom because of the GLP-1 medication, O’Donnell firmly responded.

“Never,” said the Daytime Emmy winner. “However, I stayed at 2.5 for a whole year, despite my doctor suggesting I increase my dosage. I felt fine as it was.”

O’Donnell first disclosed her use of Mounjaro in January 2023, sharing on TikTok that she had received the prescription for the drug, along with Rapatha, two months earlier.

Rosie O'Donnell performs her one-woman show "Rosie O'Donnell: Common Knowledge".
The former “View” co-host (pictured above on July 21) is planning to increase her dose “one more time.” Bruce Glikas/Getty Images
O’Donnell (pictured above on June 15) claimed she has “never” experienced a side effect. GC Images

She described it as something that changes her mindset, explaining, “It’s strange… I hardly think about food at all and have a significantly reduced appetite.”

Additionally, she mentioned, “I significantly cut back on drinking five or six Diet Cokes daily. Now, I only consume water and avoid sugar as much as possible.”

At that time, she had already lost 10 pounds and continued to showcase her “smaller body” on social media in the following years.

O’Donnell (pictured above in July 21) started taking Mounjaro in late 2022. Bruce Glikas/Getty Images
Rosie O'Donnell is seen on July 24, 2026, in New York City.
She has since lost approximately 60 pounds on the weight-loss drug. GC Images

Recently, O’Donnell credited the type 2 diabetes medication for significantly improving her health.

In a July interview with People, she expressed a desire to promote Mounjaro commercially, saying, “I wish they would lower the price instead of compensating me. I understand the shame and humiliation faced by those struggling with obesity.”

O’Donnell feels “much healthier and more empowered” thanks to her transformation.